ABSTRACT
Background & objectives: There are limited data from India on the post-COVID multisystem inflammatory syndrome in adults (MIS-A). The objective of the present study was to evaluate the clinical profile of patients with MIS-A admitted to a tertiary care centre in southern India. Methods: This single-centre retrospective study was conducted from November 2020 to July 2021, and included patients aged >18 yr admitted to the hospital as per the inclusion and exclusion criteria. Results: Nine patients (5 male, mean age 40±13 yr) met the criteria for MIS-A. Five patients had proven COVID-19 infection or contact history 36.8±11.8 days back. All patients were positive for SARS-CoV-2 IgG antibody, negative for COVID-19 PCR, and had negative blood, urine and sputum cultures. All patients had fever and gastrointestinal (GI) symptoms, and five patients had left ventricular dysfunction. All patients had neutrophilic leucocytosis at presentation and elevated biomarkers such as C-reactive protein serum procalcitonin, D-dimer and ferritin. The majority of the patients (7/9 i.e. 77.78%) were treated with intravenous hydrocortisone (50-100 mg q6h-q8h). Six patients recovered completely whereas three patients expired. Interpretation & conclusions: Fever and GI symptoms were the most common presentation of MIS-A. Elevated serum procalcitonin may not be useful in differentiating bacterial sepsis from MIS-A. Most patients responded to corticosteroids.
ABSTRACT
Background: Age related hearing loss is an universal feature of mammalian ageing and refers to sensorineural hearing impairment in elderly individuals. It was reported that increased generation of free radicals during cellular metabolism plays a major role in age related disorders. Therefore, the occurrence of age related hearing loss depends mainly on antioxidant status of the body. Hence, this study was undertaken to investigate the status of Glutathione and Superoxide dismutase in age related hearing loss. Methods: This study was conducted after the approval from institutional ethical committee. The study group included 25 patients diagnosed for age related hearing loss between the age group of 55-80 years of either sex and 25 healthy age and sex matched individuals as controls. Estimation of Glutathione was done by DTNB method and Superoxide Dismutase using standard procedures. The data was analysed using One Way ANOVA. P value less than 0.05 will be considered the level of significance. Results: The results showed that, the Glutathione level in Hearing Loss patients was increased significantly (p=0.0001) as compared to normal controls. The SOD Activity has declined significantly (p=0.001) in Hearing Loss patients as compared to normal controls. Conclusion: We found an association between the level of Glutathione and Super Oxide Dismutase in age related hearing loss. Thus the serum Glutathione and Super Oxide Dismutase level can be used as a biomarker for the assessment of age related hearing loss.